Truel1f36/4/2023 ![]() ![]() Few homozygous mutant embryos were identified during gestation, and those that did survive had a severe craniofacial defect. Twenty four tests were carried out on mutant mice and two significant abnormalities were observed. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. A conditional knockout mouse line, called Tcf7l1 tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Model organisms have been used in the study of TCF7L1 function. Model organisms Tcf7l1 knockout mouse phenotype The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. Transcription factor 7-like 1, also known as TCF7L1, is a human gene. ![]() regulation of transcription, DNA-templated.regulation of transcription by RNA polymerase II. ![]()
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